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Can I take Prilosec and omeprazole together?How do I report negative side effects of Prilosec (omeprazole)?Sep 15, 2025 · One notable side effect associated with omeprazole is muscle cramps or spasms, which may be related to hypomagnesemia (low magnesium levels in the blood) This side effect is more likely to occur with prolonged use of omeprazole, especially when taken concurrently with certain other medications Common side effects of Prilosec include diarrhea, nausea, vomiting, headaches, rash, dizziness, nervousness, abnormal heartbeats, muscle pain, weakness, and infrequently, leg cramps and water retention Consult your doctor before taking Prilosec if pregnant or breastfeeding What are the side effects of Prilosec?Can omeprazole cause muscle cramps?People also askFeb 5, 2026 · Learn about the side effects of Prilosec (omeprazole), from common to rare, for consumers and healthcare professionals Muscle cramps is reported as a side effect among people who take Prilosec (omeprazole), especially for people who are female, 60+ old, also take Zocor, and have Osteoporosis Muscle cramps is reported as a side effect among people who take Omeprazole (omeprazole), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Atenolol, and have Rheumatoid arthritis Nov 17, 2025 · Low magnesium can cause muscle cramps, weakness, and in severe cases, tetany (involuntary muscle contractions) Patients on Prilosec for more than a year, particularly those taking doses above 20 mg daily, are at higher risk Low calcium levels overstimulate nerves and muscles, leading to muscle cramps, spasms, and twitching More significant deficiency can cause tetany, a state of sustained, painful muscle contractions often with carpopedal spasms and tingling around the mouth, hands, and feet