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By selective binding to the NMDA receptors Memantine blocks the excitotoxic effects, excitation and overstimulation associated with abnormal glutamatergic transmission, thus preventing damage to those receptors, while allowing physiological transmission associated with normal cell functioning Sep 22, 2026 · The Europe Memantine Market encompasses the supply, regulation, and application of memantine-based therapeutics across diverse European healthcare systems List of Marketing Authorisations (MA) containing Memantine registered and approved in Europe on PharmaCompass comList of Marketing Authorisations (MA) containing Memantine - Memantine Hydrochloride registered and approved in Europe on PharmaCompass comOn 6 September 2024, the European Commission withdrew the marketing authorisation for Memantine LEK (memantine hydrochloride) in the European Union (EU) Memantine was first synthesized and patented by Eli Lilly and Company in 1968 (as cited in the Merck Index), and then developed by Merz in collaboration with Neurobiological Technologies, Inc and licensed to Forest for the U S and Lundbeck for selected European and international markets Memantine is an NMDA receptor antagonist primarily used to treat neurodegenerative conditions like Alzheimer’s disease It works by regulating glutamate activity in the brain, which can help improve memory, cognition, and overall brain function